Conclusions: Three key subelements, nt453-434, nt403-384 and nt283-264 sequence, were successfully identified in the negative regulatory element on hepatitis B virus.
結(jié)論:HBV nt453-434、nt403-384和nt283-264序列為HBV nt250-453負(fù)性調(diào)節(jié)元件中發(fā)揮關(guān)鍵作用的三個(gè)亞元件;這三個(gè)亞元件可以獨(dú)立發(fā)揮作用;當(dāng)以協(xié)同的方式發(fā)揮作用時(shí),則表現(xiàn)出最強(qiáng)的負(fù)性調(diào)節(jié)作用。